diff --git a/mingw-w64-python-llvmlite/PKGBUILD b/mingw-w64-python-llvmlite/PKGBUILD
index ed0c149a8a..fc195856b3 100644
--- a/mingw-w64-python-llvmlite/PKGBUILD
+++ b/mingw-w64-python-llvmlite/PKGBUILD
@@ -3,8 +3,8 @@
 _realname=llvmlite
 pkgbase=mingw-w64-python-${_realname}
 pkgname=("${MINGW_PACKAGE_PREFIX}-python-${_realname}")
-pkgver=0.44.0
-pkgrel=2
+pkgver=0.45.0
+pkgrel=1
 pkgdesc='Lightweight LLVM python binding for writing JIT compilers (mingw-w64)'
 arch=('any')
 mingw_arch=('mingw64' 'ucrt64' 'clang64' 'clangarm64')
@@ -23,13 +23,11 @@ makedepends=("${MINGW_PACKAGE_PREFIX}-python-build"
              "${MINGW_PACKAGE_PREFIX}-cc"
              "${MINGW_PACKAGE_PREFIX}-cmake"
              "${MINGW_PACKAGE_PREFIX}-ninja"
-             "${MINGW_PACKAGE_PREFIX}-llvm-16"
-             "${MINGW_PACKAGE_PREFIX}-compiler-rt-16")
+             "${MINGW_PACKAGE_PREFIX}-llvm-20"
+             "${MINGW_PACKAGE_PREFIX}-compiler-rt-20")
 source=("https://pypi.org/packages/source/${_realname::1}/${_realname}/${_realname}-${pkgver}.tar.gz"
-        "multi-defs.patch"
         "path_fix.patch")
-sha256sums=('07667d66a5d150abed9157ab6c0b9393c9356f229784a4385c02f99e94fc94d4'
-            'b4610934ac8fd7e614d9ea920856ff6da2fbeb146028a664ada8543b8b33ec56'
+sha256sums=('ceb0bcd20da949178bd7ab78af8de73e9f3c483ac46b5bef39f06a4862aa8336'
             '813ecc48f18543f0d36b03c7596a1a6a26be31b9cfa44f1111ac232821844a79')
 
 apply_patch_with_msg() {
@@ -44,7 +42,6 @@ prepare() {
   cd "${_realname}-${pkgver}"
 
   apply_patch_with_msg \
-    multi-defs.patch \
     path_fix.patch
 
   sed -i "s,_MSC_VER,_WIN32," ffi/core.h
@@ -54,7 +51,7 @@ build() {
   cp -r "${_realname}-${pkgver}" "python-build-${MSYSTEM}" && cd "python-build-${MSYSTEM}"
 
   export CMAKE_GENERATOR="Ninja"
-  export LLVM_DIR=${MINGW_PREFIX}/opt/llvm-16/lib/cmake/llvm
+  export LLVM_DIR=${MINGW_PREFIX}/opt/llvm-20/lib/cmake/llvm
 
   python -m build --wheel --skip-dependency-check --no-isolation
 }
diff --git a/mingw-w64-python-llvmlite/multi-defs.patch b/mingw-w64-python-llvmlite/multi-defs.patch
deleted file mode 100644
index a2dacb7c69..0000000000
--- a/mingw-w64-python-llvmlite/multi-defs.patch
+++ /dev/null
@@ -1,12 +0,0 @@
---- llvmlite-0.34.0rc1/ffi/CMakeLists.txt.old	2020-08-05 13:33:58.000000000 -0700
-+++ llvmlite-0.34.0rc1/ffi/CMakeLists.txt	2020-08-11 17:01:54.888723700 -0700
-@@ -49,5 +49,9 @@
- # so the "OptRemarks" library is removed from this list.
- list(REMOVE_ITEM llvm_libs "OptRemarks")
- 
-+# Multiple definition error workaround
-+list(REMOVE_ITEM llvm_libs "LLVM")
-+list(REMOVE_ITEM llvm_libs "LTO")
-+
- # Link against LLVM libraries
- target_link_libraries(llvmlite ${llvm_libs})