--- a/setup.py
+++ b/setup.py
@@ -299,25 +299,25 @@
         lambda x: "third_party/boringssl" not in x, CORE_C_FILES
     )
     CORE_C_FILES = filter(lambda x: "src/boringssl" not in x, CORE_C_FILES)
-    SSL_INCLUDE = (os.path.join("/usr", "include", "openssl"),)
+    SSL_INCLUDE = (os.path.join(sys.prefix, "include", "openssl"),)
 
 if BUILD_WITH_SYSTEM_ZLIB:
     CORE_C_FILES = filter(lambda x: "third_party/zlib" not in x, CORE_C_FILES)
-    ZLIB_INCLUDE = (os.path.join("/usr", "include"),)
+    ZLIB_INCLUDE = (os.path.join(sys.prefix, "include"),)
 
 if BUILD_WITH_SYSTEM_CARES:
     CORE_C_FILES = filter(lambda x: "third_party/cares" not in x, CORE_C_FILES)
-    CARES_INCLUDE = (os.path.join("/usr", "include"),)
+    CARES_INCLUDE = (os.path.join(sys.prefix, "include"),)
 
 if BUILD_WITH_SYSTEM_RE2:
     CORE_C_FILES = filter(lambda x: "third_party/re2" not in x, CORE_C_FILES)
-    RE2_INCLUDE = (os.path.join("/usr", "include", "re2"),)
+    RE2_INCLUDE = (os.path.join(sys.prefix, "include", "re2"),)
 
 if BUILD_WITH_SYSTEM_ABSL:
     CORE_C_FILES = filter(
         lambda x: "third_party/abseil-cpp" not in x, CORE_C_FILES
     )
-    ABSL_INCLUDE = (os.path.join("/usr", "include"),)
+    ABSL_INCLUDE = (os.path.join(sys.prefix, "include"),)
 
 EXTENSION_INCLUDE_DIRECTORIES = (
     (PYTHON_STEM,)
@@ -344,6 +344,7 @@
     EXTENSION_LIBRARIES += (
         "advapi32",
         "bcrypt",
+        "crypt32",
         "dbghelp",
         "ws2_32",
     )
@@ -360,8 +361,8 @@
     EXTENSION_LIBRARIES += ("re2",)
 if BUILD_WITH_SYSTEM_ABSL:
     EXTENSION_LIBRARIES += tuple(
-        lib.stem[3:]
-        for lib in sorted(pathlib.Path("/usr").glob("lib*/libabsl_*.so"))
+        lib.stem[3:-4]
+        for lib in sorted(pathlib.Path(sys.prefix).glob("lib*/libabsl_*.dll.a"))
     )
 
 DEFINE_MACROS = (("_WIN32_WINNT", 0x600),)
@@ -418,7 +419,6 @@
     # ares_library_init compilation issue
     DEFINE_MACROS += (
         ("WIN32_LEAN_AND_MEAN", 1),
-        ("CARES_STATICLIB", 1),
         ("GRPC_ARES", 0),
         ("NTDDI_VERSION", 0x06000000),
         ("NOMINMAX", 1),