diff --git a/cmake/FindPythonLibsNew.cmake b/cmake/FindPythonLibsNew.cmake
index 919a384..931d49e 100644
--- a/cmake/FindPythonLibsNew.cmake
+++ b/cmake/FindPythonLibsNew.cmake
@@ -141,7 +141,7 @@ string(REGEX REPLACE "\\\\" "/" PYTHON_PREFIX ${PYTHON_PREFIX})
 string(REGEX REPLACE "\\\\" "/" PYTHON_INCLUDE_DIR ${PYTHON_INCLUDE_DIR})
 string(REGEX REPLACE "\\\\" "/" PYTHON_SITE_PACKAGES ${PYTHON_SITE_PACKAGES})
 
-if(CMAKE_HOST_WIN32)
+if(CMAKE_HOST_WIN32 AND NOT (MSYS OR MINGW))
     set(PYTHON_LIBRARY
         "${PYTHON_PREFIX}/libs/Python${PYTHON_LIBRARY_SUFFIX}.lib")
 
diff --git a/setup.py b/setup.py
index 79e91b6..1f32d2f 100644
--- a/setup.py
+++ b/setup.py
@@ -201,7 +201,7 @@ class BuildLibrary(build_ext):
             ]
 
 
-        if platform.system() == "Windows":
+        if platform.system() == "Windows" and not sysconfig.get_platform().startswith("mingw"):
             from setuptools import msvc
 
             cmake_args += [
@@ -241,7 +241,7 @@ class BuildLibrary(build_ext):
         if self.distribution.doc:
             targets['doc'] = "lief-doc"
 
-        if platform.system() == "Windows":
+        if platform.system() == "Windows" and not sysconfig.get_platform().startswith("mingw"):
             build_cmd = ['cmake', '--build', '.', '--target', "lief_samples"] + build_args
             #log.info(" ".join(build_cmd))
 
@@ -299,7 +299,7 @@ class BuildLibrary(build_ext):
         libsuffix = pylief_dst.split(".")[-1]
 
         pylief_path = os.path.join(cmake_library_output_directory, "{}.{}".format(PACKAGE_NAME, libsuffix))
-        if platform.system() == "Windows":
+        if platform.system() == "Windows" and not sysconfig.get_platform().startswith("mingw"):
             pylief_base = pathlib.Path(cmake_library_output_directory) / "Release" / "api" / "python"
             pylief_path = pylief_base / "Release" / "{}.{}".format(PACKAGE_NAME, libsuffix)
             if not pylief_path.is_file():