--- a/setup.py
+++ b/setup.py
@@ -330,7 +330,7 @@
 
 
 def load_libraries():
-    if os.getenv("NIX_STORE"):
+    if os.getenv("NIX_STORE") or os.getenv("MINGW_PREFIX"):
         return LIBRARIES["nix"]
 
     try:
@@ -525,7 +525,8 @@
 openbsd = platform.system() == 'OpenBSD'
 freebsd = platform.system() == 'FreeBSD'
 darwin  = platform.system() == 'Darwin'
-windows = platform.system() == 'Windows' or platform.system().startswith('CYGWIN')
+windows = (platform.system() == 'Windows' and "MSC" in sys.version) or platform.system().startswith('CYGWIN')
+mingw   = platform.system() == 'Windows' and "MSC" not in sys.version
 
 if 'sdist' in sys.argv:
     # Create local mupdf.tgz, for inclusion in sdist.
@@ -711,6 +712,16 @@
                     'harfbuzz',
                     ]
 
+    elif mingw:
+        mingw_prefix = os.getenv("MINGW_PREFIX", "/mingw64")
+        include_dirs.append( f'{mingw_prefix}/include/mupdf')
+        include_dirs.append( f'{mingw_prefix}/include/freetype2')
+        extra_compile_args.append( '-Wno-incompatible-pointer-types')
+        extra_compile_args.append( '-Wno-pointer-sign')
+        extra_compile_args.append( '-Wno-sign-compare')
+        libraries = load_libraries()
+        libraries += ['z']
+
     elif windows:
         # Windows.
         assert mupdf_local