diff -Naur a/Lib/ctypes/__init__.py b/Lib/ctypes/__init__.py --- a/Lib/ctypes/__init__.py 2014-05-31 22:58:38.000000000 +0400 +++ b/Lib/ctypes/__init__.py 2014-06-03 08:14:50.721600000 +0400 @@ -445,7 +445,9 @@ cdll = LibraryLoader(CDLL) pydll = LibraryLoader(PyDLL) -if _os.name in ("nt", "ce"): +if _os.name == "nt" and _sys.version.find('GCC') >= 0: + pythonapi = PyDLL("libpython%d.%d.dll" % _sys.version_info[:2], None) +elif _os.name in ("nt", "ce"): pythonapi = PyDLL("python dll", None, _sys.dllhandle) elif _sys.platform == "cygwin": pythonapi = PyDLL("libpython%d.%d.dll" % _sys.version_info[:2])